Purpose: To study patient's acceptability and safety of offering a prophylactic early single session of pan-retinal photocoagulation (PRP) for moderate nonproliferative diabetic retinopathy (NPDR) in selected patients. Settings and Design: Mixed observational and interventional study. Patients and Methods: The observational study included 82 eyes of 68 patients presenting with proliferative diabetic retinopathy (PDR) or its complications and the interventional study included 48 eyes of 48 patients with moderate NPDR who were offered a single session PRP because they were unlikely to comply with the follow-up protocol and were at higher risk of diabetic retinopathy (DR) progression. Results: The observational study showed that nearly 51% of patients had no idea about the DR screening protocols, 47.5% of included eyes presented with vitreous hemorrhage, 30.5% with tractional retinal detachment, and 22% with retinal neovascularization. The interventional study showed that minor patients' complaints were reported such as night vision problems, flashes, and peripheral field defects. There was no significant change in the mean preoperative logarithm of the minimum angle of resolution (logMAR) corrected distance visual acuity (CDVA) over time throughout the study (P = 0.951). At the end of follow-up, 89.5% of included eyes showed no loss of any lines of their preoperative logMAR CDVA and 10.5% lost only one line. All eyes remained in the same stage of moderate NPDR with no signs of progression to severe or very severe NPDR or proliferative DR. Conclusion: Prophylactic early PRP is an acceptable, safe, and satisfactory procedure for patients with moderate NPDR in low-resource settings.

Purpose: The purpose of this study was to compare the automated and manual choroidal thickness (CT) measures in normal eyes using swept-source optical coherence tomography (SS-OCT). Patients and Methods: This prospective study included 80 eyes from 40 normal volunteers. CT was measured manually and automatically in all eyes using Topcon deep-range imaging-1 SS-OCT. Automatically calculated measures, which are shown as a colored topographic map with nine subfields, defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) style grid, compared to manual measures at the subfoveal area, at four points 1 mm around the fovea as well as at four points 3 mm around the fovea. Results: The mean subfoveal CT (SFCT) was 271.77 ± 78.78 μm for the automatically measured ETDRS map and 282.81 ± 83.74 μm for the manual SFCT measurements. The difference between manual and automated measurement was the smallest in SFCT at 11.03 ± 35 μm and the greatest in the outer temporal area at 48.36 ± 49.83 μm. Manually measured CT was significantly higher (P < 0.001) in all nine areas compared to automated ETDRS map measurements. Conclusions: Manual measurement of CT is significantly higher than automated measurements. In addition, they cannot replace automated methods.

Paracentral acute middle maculopathy (PAMM) can be caused by a variety of retinal, ocular, iatrogenic, and systemic factors. Patients with PAMM typically have a sudden onset of paracentral scotomata, difficulty focusing, and/or blurred central vision. Isotretinoin is associated with multiple ocular side effects, including eye dryness and loss of night vision. In this study, we present a case of PAMM after 13 months of isotretinoin treatment with no evidence of other causes or relevant medical history.